Liver Cancer

Personalised treatments designed to fight cancer while minimising side effects.

What is Liver Cancer?

Liver cancer occurs when malignant (cancerous) cells form in the tissues of the liver. The liver is one of the body’s most vital organs, responsible for detoxifying harmful substances, producing bile for digestion, and storing nutrients. Primary liver cancer begins in the liver itself (most commonly hepatocellular carcinoma), while secondary or metastatic liver cancer originates in another part of the body and spreads to the liver.

How Common is Liver Cancer in Singapore?

According to GLOBOCAN 2022, liver cancer is a serious health concern in Singapore. It is the 4th most common cancer in men and accounts for a significant proportion of cancer-related deaths. In 2022, there were approximately 1,442 new cases and 1,353 deaths recorded in Singapore. The high mortality reflects the tendency for liver cancer to be diagnosed at advanced stages, where curative treatment is often not possible. Chronic hepatitis B and C infections remain major contributing factors in the region. 

What Are the Signs and Symptoms of Liver Cancer?

In the early stages, liver cancer may not cause symptoms. As the disease progresses, common symptoms include:

How is Liver Cancer Diagnosed?

Diagnosis typically involves a combination of:

  • Blood tests such as liver function tests and alpha-fetoprotein (AFP) marker
  • Imaging tests, including ultrasound, CT scan, or MRI scan
  • Liver biopsy to confirm the diagnosis

What Are the Causes and Risk Factors of Liver Cancer?

Key risk factors include:

What Are the Types of Liver Cancer?

Hepatocellular carcinoma (HCC)

The most common type, arising from liver cells

Originates in the bile ducts

Rare forms of liver cancer

What Are the Stages of Liver Cancer?

Liver cancer staging considers tumour size, spread within the liver, invasion into blood vessels, and spread to distant organs. Stages range from Stage I (localised) to Stage IV (advanced/metastatic).

What are Liver Cancer Treatments?

Treatment options depend on the stage of disease, liver function, and overall health. They include:

Surgery

Liver resection or transplantation in selected patients. Surgery offers the best chance of cure but is only suitable if the cancer has not spread extensively and the liver is still functioning well.

Local therapies

Radiofrequency ablation, microwave ablation, and percutaneous ethanol injection directly target the tumour. Transarterial chemoembolisation (TACE) and selective internal radiation therapy (SIRT) deliver drugs or radiation directly into the liver tumour through its blood supply.

Radiotherapy

External beam radiotherapy or internal radiation may be used when surgery is not possible.

Systemic therapies

Systemic treatment includes immunotherapy based regimens and targeted agents such as Sorafenib and Lenvatinib. These are options when surgery or local therapies are not suitable.

Supportive care

Focused on relieving symptoms, improving nutrition, and maintaining quality of life.

Each treatment option has its own side effects. Surgery may carry risks such as bleeding and infection, while systemic therapies and chemotherapy can cause fatigue, diarrhoea, or skin reactions. Your doctor will discuss the risks and benefits of each treatment and tailor a plan to your needs.

Meet Our Doctors

At OncoCare Singapore, our multidisciplinary team includes medical oncologists specialising in gastrointestinal and hepatobiliary cancers, liver surgeons experienced in advanced and minimally invasive procedures, radiation oncologists, radiologists, pathologists, oncology nurses, dietitians, and psycho-oncology counsellors. Together, they design an individualised treatment plan for every patient.

If you have risk factors or symptoms that may suggest liver cancer, seeking early consultation with our specialists is important. Timely diagnosis offers the best chance for effective treatment and improved outcomes.

Senior Medical Oncologist
Senior Medical Oncologist
Senior Medical Oncologist
Senior Medical Oncologist
Senior Medical Oncologist
Senior Medical Oncologist
Senior Medical Oncologist
Senior Medical Oncologist
Senior Medical Oncologist